Increased blood viscosity9/9/2023 ![]() This study was designed to test the hypothesis that soluble fibrin complexes resulting from the trauma of surgery could produce elevated blood viscosity, to characterize the soluble fibrin polymers, and to evaluate in vitro the effect of a new hemorheologic agent, poloxamer 188, on viscosity in these abnormal situations. ![]() Clin Hemorheol Microcirc 48, 257-263.PDF Download Buy Article Permissions and Reprints Summary ![]() Both overall adiposity and abdominal adiposity increase blood viscosity by separate mechanisms. Am J Physiol Regul Integr Comp Physiol 318, R49-R56.īrun J-F, Varlet-Marie E, Raynaud de Mauverger E & Mercier J (2011). Increased hypoxic proliferative response and gene expression in erythroid progenitor cells of Andean highlanders with chronic mountain sickness. 1), 8655-8660.īermudez D, Azad P, Figueroa-Mujíca R, Vizcardo-Galindo G, Corante N, Guerra-Giraldez C, Haddad GG & Villafuerte FC (2020). Two routes to functional adaptation: Tibetan and Andean high-altitude natives. New guidelines for hemorheological laboratory techniques. Clin Hemorheol Microcirc 55, 55-62.īaskurt OK, Boynard M, Cokelet GC, Connes P, Cooke BM, Forconi S, Liao F, Hardeman MR, Jung F, Meiselman HJ, Nash G, Nemeth N, Neu B, Sandhagen B, Shin S, Thurston G, Wautier JL & International Expert Panel for Standardization of Hemorheological Methods (2009). Red blood cell mechanical stability test. The Journal of Physiology © 2020 The Physiological Society.īaskurt OK & Meiselman HJ (2013). In conclusion, blood viscosity may contribute to CMS symptomatology but the increased blood viscosity in CMS patients cannot solely be explained by the rise in haematocrit.Ĭhronic mountain sickness haemorheology high-altitude native hypoxia. At 5100 m, blood viscosity at corrected haematocrit was higher in highlanders with moderate-to-severe CMS (at 45 s -1 : 18.9 ± 10.7 mPa s) than in highlanders without CMS (10.2 ± 5.9 mPa s) or with mild CMS (12.1 ± 6.1 mPa s) (P < 0.05). Blood viscosity also increased with altitude (at 45 s -1 : 6.7 ± 0.9 mPa s at sea level, 14.0 ± 2.0 mPa s at 3800 m and 27.1 ± 8.8 mPa s at 5100 m P < 0.001). Haemoglobin concentration and haematocrit increased with the altitude of residency. Blood viscosity was measured at native and corrected haematocrit (40%). Ninety-three men participated in this study: 10 Caucasian lowlanders, 13 Andean highlanders living at 3800 m and 70 Andean highlanders living at 5100 m (35 asymptomatic, CMS score ≤5 15 with mild CMS, CMS score between 6 and 10 20 with moderate-to-severe CMS, CMS score >10). We assessed the effect of living at high altitude on haemoglobin, haematocrit and haemorheological parameters (blood viscosity and red blood cell aggregation), and investigated their relationship with CMS in highlanders living in the highest city in the world (La Rinconada, Peru, 5100 m). While EE is thought to increase blood viscosity and subsequently to trigger CMS symptoms, the exact relationship between blood viscosity and CMS symptoms remains incompletely understood. Blood viscosity may contribute to CMS symptomatology but the increased blood viscosity in CMS patients cannot solely be explained by the rise in haematocrit.Ĭhronic mountain sickness (CMS) is a condition characterised by excessive erythrocytosis (EE). At 5100 m, highlanders with moderate-to-severe CMS had higher blood viscosity mainly at high shear rate and even at corrected haematocrit (40%), with a lower red blood cell aggregation. Blood viscosity increased with altitude, together with haemoglobin concentration and haematocrit. This study aimed to assess the effects of permanent life at high altitude on clinical and haemorheological parameters (blood viscosity and red blood cell aggregation) and to compare clinical and haemorheological parameters of dwellers from the highest city in the world according to CMS severity. However, a significant proportion of populations living permanently at high altitude develop maladaptive features known as chronic mountain sickness (CMS). Highlanders develop unique adaptative mechanisms to chronic hypoxic exposure, including substantial haemoglobin and haematocrit increases.
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